Harvey Stancer Research Day 2020

On June 18th, 2020 the Matthews lab attended the virtual conference: The Harvey Stancer Research Day. It is the major research conference for the Department of Psychiatry at the University of Toronto. This event allows researchers to present their work to one another and to the public, to promote developing scientists. Further information can be found here. Congratulations to Cindy Zhang for receiving the best graphical abstract by a graduate student award! The projects from the Matthe...
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New Publication in Frontiers in Genetics

Publication title: Impact of ex vivo Sample Handling on DNA Methylation Profiles in Human Cord Blood and Neonatal Dried Blood Spots   This study investigated the sensitivity of DNA methylation profiles to ex vivo sample handling prior to storage to guide future studies examining DNA methylation modifications in whole blood. The citation for this article can be found on the “Publications” page of the website, under the tab titled “The Lab.” Alternatively, the article can also b...
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4th DOHaD Canada Annual Scientific Meeting (DOHaD Canada 2020) and 7th Canadian National Perinatal Research Meeting (CNPRM 2020)

Date: February 11-12th, 2020 February 12-15th, 2020 The Matthews Lab attended the 4th DOHaD Canada / 7th CNPRM held in Banff, Alberta. Approximately 300 researchers, trainees, clinicians and policy leaders across Canada participated the meeting. The Program included keynote lecture by Dr. Lucilla Poston, Head of the Department of Women and Children’s Health at King’s College London, trainee flash talks, concurrent sessions, and poster sessions, from the fields of obstetrics and gynecology...
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Physiology Holiday Luncheon

  Thursday December 12, 2019 The lab got together for a departmental holiday luncheon at the Faculty Club on Thursday December 12, 2019.  Everyone had a fun time connecting with colleagues in the department and enjoying the great food! The Matthews Lab also showcased their competitive spirit by winning physiology trivia! A few members in the lab also won raffle prizes, great job everyone!    
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DOHaD World Congress (DOHaD 2019)

The Matthews Lab attended the 11th DOHaD World Congress in Melbourne, Australia, hosted by the DOHaD Society of Australia and New Zealand from October 20th-23rd 2019. The Congress theme was “Investing in a Healthy Future for All: Research, Education, and Policy.” The Congress brought together basic and clinical researchers and health care professionals from around the world to address the many challenges that currently impact the health of mothers and fathers, babies in the womb, infants, ch...
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Developmental and Perinatal Biology 2019 at the Karolinska-Institutet

From August 18-24 2019, the Matthews Lab participated in the 23rd annual exchange in developmental and perinatal biology between the University of Toronto and the Karolinska Institute in Stockholm Sweden. The projects from the Matthews Lab that were presented at Karolinska are as follows: Antenatal Synthetic Glucocorticoid Programming of Post-natal Blood-brain Barrier Function (Elizabeth Eng – Poster presentation) Differential DNA methylation from various time-to-freeze periods o...
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Canadian Physiological Society Conference

On May 21st 2019, the Matthews lab attended the CPS trainee and awards symposium. This event promoted Canadian physiology and engagement within the physiological society. The projects from the Matthews Lab that were presented at CPS are as follows: The intergenerational effects of synthetic glucocorticoid exposure during the paternal preconception period (Chris Casciaro – Poster presentation) Seasonality and the immune system during pregnancy: Implications for child neurodevelopment and...
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Southern Ontario Reproduction Biology Meeting

  On Friday June 7, 2019, the Matthews Lab attended the annual SORB meeting. This meeting provided an important platform for trainees around Ontario to present their research. This was the 47th annual SORB meeting, which welcomed Dr. Miguel Ramalho-Santosas the Keynote Speaker. Dr. Ramalho-Santos, from the University of Toronto, is the Canada 150 Research Chair in Developmental Epigenetics and is known for his pioneering work in the transcriptional profiling of mouse stem cells...
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New Publication in the Journal of Nutritional Biochemistry

  Publication title: Maternal malnutrition impacts placental morphology and transporter expression: an origin for poor offspring growth. This study investigated placental adaptations, maternal metabolism and fetal growth after maternal UN and HF diets. This paper provides new insights to the mechanisms underlying the developmental origins of later disease.   The citation for this article can be found on the “Publications” page of the website, under the tab titled “The ...
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New Publication in Scientific Reports

Publication title: Prenatal Glucocorticoid Exposure Results in Changes in Gene Transcription and DNA Methylation in the Female Juvenile Guinea Pig Hippocampus Across Three Generations. This study investigated the mechanisms involved in transgenerational transmission and highlights the long-term effects of antenatal sGC on hippocampal-related function.   The citation for this article can be found on the “Publications” page of the website, under the tab titled “The Lab.” Alterna...
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New Publication in Cells

Publication title: Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibits Extra Villous Trophoblast Migration: The Impact of Bacterial and Viral Infection This study investigated the function of BCRP in early placentation and how exposure of EVTs to maternal infection/inflammation could disrupt their migration potential. The citation for this article can be found on the “Publications” page of the website, under the tab titled “The Lab.” Alternatively, the article can also be accessed her...
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New Publication in Scientific Reports

Publication title: Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor. This study investigated whether the expression of key placental ABC transporters is associated with the pathological and clinical features of human malaria during pregnancy. The citation for this article can be found on the “Publications” page of the website, under the tab titled “The Lab.” Alternatively, the article can also be accessed here.
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New Publication in the Journal of Endocrinology

Publication title: Developmental programming of the HPA axis and related behaviours: epigenetic mechanisms. This paper is part of a thematic section on 30 Years of the Developmental Endocrinology of Health and Disease. The paper highlights the mechanistic studies linking early exposures to adversity with changes in gene regulatory mechanisms.   The citation for this article can be found on the “Publications” page of the website, under the tab titled “The Lab.” Alternatively, th...
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