Click here for a list of publications by Dr. Stephen G. Matthews.

Recent Publications

Casciaro C, Hamada H, Kostaki A, Matthews SG. Glucocorticoid exposure modifies the miRNA profile of sperm in the guinea pig: Implications for intergenerational transmission. FASEB J. 2023 Apr;37(4):e22879. doi: 10.1096/fj.202201784R. PMID: 36928999.

Kumaran K, Birken C, Baillargeon JP, Dennis CL, Fraser WD, Huang H, Fan J, Lye S, Matthews SG, Norris SA. An intergenerational life-course approach to address early childhood obesity and adiposity: the Healthy Life Trajectories Initiative (HeLTI). Lancet Glob Health. 2023 Mar;11 Suppl 1:S15. doi: 10.1016/S2214-109X(23)00098-0. PMID: 36866472.

Lye P, Bloise E, Matthews SG. Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood-brain barrier. Fluids Barriers CNS. 2023 Jan 31;20(1):8. doi: 10.1186/s12987-023-00409-4. PMID: 36721242; PMCID: PMC9887585.

Andrade CBV, Lopes LVA, Ortiga-Carvalho TM, Matthews SG, Bloise E. Infection and disruption of placental multidrug resistance (MDR) transporters: Implications for fetal drug exposure. Toxicol Appl Pharmacol. 2023 Jan 15;459:116344. doi: 10.1016/j.taap.2022.116344. PMID: 36526072.

Levitan RD, Sqapi M, Post M, Knight JA, Lye SJ, Matthews SG. Increasing maternal age predicts placental protein expression critical for fetal serotonin metabolism: Potential implications for neurodevelopmental research. Placenta. 2022 Dec;130:9-11. doi: 10.1016/j.placenta.2022.10.009. PMID: 36343528.

Lye P, Bloise E, Imperio GE, Chitayat D, Matthews SG. Functional Expression of Multidrug-Resistance (MDR) Transporters in Developing Human Fetal Brain Endothelial Cells. Cells. 2022 Jul 21;11(14):2259. doi: 10.3390/cells11142259. PMID: 35883702; PMCID: PMC9323234.

Eng ME, Imperio GE, Bloise E, Matthews SG. ATP-binding cassette (ABC) drug transporters in the developing blood-brain barrier: role in fetal brain protection. Cell Mol Life Sci. 2022 Jul 11;79(8):415. doi: 10.1007/s00018-022-04432-w. PMID: 35821142.

Lye JM, Knight JA, Arneja J, Seeto RA, Wong J, Adel Khani N, Brooks JD, Levitan RD, Matthews SG, Lye SJ, Hung RJ. Maternal acetaminophen use and cognitive development at 4 years: the Ontario Birth Study. Pediatr Res. 2023 Mar;93(4):959-963. doi: 10.1038/s41390-022-02182-w. PMID: 35794252; PMCID: PMC9261144.

Monteiro VRS, Andrade CBV, Gomes HR, Reginatto MW, Império GE, Fontes KN, Spiess DA, Rangel-Junior WS, Nascimento VMO, Lima COS, Sousa RPC, Bloise FF, Matthews SG, Bloise E, Pimentel-Coelho PM, Ortiga-Carvalho TM. Mid-pregnancy poly(I:C) viral mimic disrupts placental ABC transporter expression and leads to long-term offspring motor and cognitive dysfunction. Sci Rep. 2022 Jun 17;12(1):10262. doi: 10.1038/s41598-022-14248-0. PMID: 35715474; PMCID: PMC9205917.

Sasaki A, Murphy KE, Briollais L, McGowan PO, Matthews SG. DNA methylation profiles in the blood of newborn term infants born to mothers with obesity. PLoS One. 2022 May 2;17(5):e0267946. doi: 10.1371/journal.pone.0267946. PMID: 35500004; PMCID: PMC9060365.

Norris SA, Draper CE, Prioreschi A, Smuts CM, Ware LJ, Dennis C, Awadalla P, Bassani D, Bhutta Z, Briollais L, Cameron DW, Chirwa T, Fallon B, Gray CM, Hamilton J, Jamison J, Jaspan H, Jenkins J, Kahn K, Kengne AP, Lambert EV, Levitt N, Martin MC, Ramsay M, Roth D, Scherer S, Sellen D, Slemming W, Sloboda D, Szyf M, Tollman S, Tomlinson M, Tough S, Matthews SG, Richter L, Lye S. Building knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (Bukhali): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI). BMJ Open. 2022 Apr 21;12(4):e059914. doi: 10.1136/bmjopen-2021-059914. PMID: 35450913; PMCID: PMC9024255.

Martin WN, Wang CA, Lye SJ, Reynolds RM, Matthews SG, McLaughlin CE, Oldmeadow C, Mori TA, Beilin L, Smith R, Pennell CE. Defining the role of the hypothalamic-pituitary-adrenal axis in the relationship between fetal growth and adult cardiometabolic outcomes. J Dev Orig Health Dis. 2022 Dec;13(6):683-694. doi: 10.1017/S2040174422000186. PMID: 35445653.

Ssewanyana D, Knight JA, Matthews SG, Wong J, Khani NA, Lye J, Murphy KE, Foshay K, Okeke J, Lye SJ, Hung RJ. Correction: Maternal prenatal psychological distress and vitamin intake with children’s neurocognitive development. Pediatr Res. 2022 Nov;92(5):1487. doi: 10.1038/s41390-022-02057-0. Erratum for: Pediatr Res. 2022 Nov;92(5):1450-1457. PMID: 35411070.

Kim B, Sasaki A, Murphy K, Matthews SG. DNA methylation signatures in human neonatal blood following maternal antenatal corticosteroid treatment. Transl Psychiatry. 2022 Mar 31;12(1):132. doi: 10.1038/s41398-022-01902-4. PMID: 35354798; PMCID: PMC8967826.

Eng ME, Bloise E, Matthews SG. Fetal glucocorticoid exposure leads to sex-specific changes in drug-transporter function at the blood-brain barrier in juvenile guinea pigs. FASEB J. 2022 Apr;36(4):e22245. doi: 10.1096/fj.202101552RR. PMID: 35262963; PMCID: PMC9311705.

Zhang CXW, Okeke JC, Levitan RD, Murphy KE, Foshay K, Lye SJ, Knight JA, Matthews SG. Evaluating depression and anxiety throughout pregnancy and after birth: impact of the COVID-19 pandemic. Am J Obstet Gynecol MFM. 2022 May;4(3):100605. doi: 10.1016/j.ajogmf.2022.100605. PMID: 35257937; PMCID: PMC8895717.