Publication title: Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor. This study investigated whether the expression of key placental ABC transporters is associated with the pathological and clinical features of human malaria during pregnancy. The citation for this article can be found on the “Publications” page of the website, under the tab titled “The Lab.” Alternatively, the article can also be accessed here.

Publication title: Developmental programming of the HPA axis and related behaviours: epigenetic mechanisms. This paper is part of a thematic section on 30 Years of the Developmental Endocrinology of Health and Disease. The paper highlights the mechanistic studies linking early exposures to adversity with changes in gene regulatory mechanisms.   The citation for this article can be found on the “Publications” page of the website, under the tab titled “The Lab.” Alternatively, th...

  Between March 12th and March 16th 2019, the Matthews Lab (Andrada, Dr. Sasaki, Dr. Imperio, and Dr. Matthews) attended the 66th Annual Meeting of the Society for Reproductive Investigation (SRI) in Paris, France. The meeting is provides a a platform for some of the leading scientists in the world to share their research in reproductive sciences and women's health. It also provides a tremendous opportunity for trainees to share their own research and learn from the leaders in their ...

Publication title: Prenatal programming of stress responsiveness and behaviours: Progress and perspectives. Congratulations to Dr. Hamada and Professor Matthews on the publication of their manuscript. The citation for this article can be found on the "Publications" page of the website, under the tab titled "The Lab." Alternatively, the article can also be accessed here. This review highlighted the key literature pertaining to parental stress prior to conception and during pregnancy, an...

Publication title: Genome-wide epigenetic signatures of childhood adversity in early life: Opportunities and challenges. Congratulations to Dr. Sasaki and Professor Matthews on the publication of their manuscript. The citation for this article can be found on the "Publications" page of the website, under the tab titled "The Lab." Alternatively, the article can also be accessed here. This review highlighted the key literature pertaining to early childhood adversity and the associated ep...

Publication title: Antenatal Glucocorticoid Exposure Results in Sex-Specific and Transgenerational Changes in Prefrontal Cortex Gene Transcription that Relate to Behavioural Outcomes. Congratulations to Dr. Constantinof, Dr. Moisiadis, Alisa Kostaki, and Professor Matthews on the publication of their manuscript. The citation for this article can be found on the "Publications" page of the website, under the tab titled "The Lab." Alternatively, the article can also be accessed here. This...

  Publication title: Gestational age-dependent gene expression profiling of ATP-binding cassette transporters in the healthy human placenta. Congratulations to Dr. Imperio, Mohsen Javam, Tam Lye, Dr. Constantinof, and Professor Matthews on the publication of their manuscript. The citation for this article can be found on the "Publications" page of the website, under the tab titled "The Lab." Alternatively, the article can also be accessed here. This study aimed to investigate t...

Publication title: A Single Course of Synthetic Gluococorticoids in Pregnant Guinea Pigs Programs Behaviour and Stress Response in Two Generations of Offspring Congratulations to Dr. Moisiadis, Alexandros Mouratidis, Alisa Kostaki, and Professor Matthews on the acceptance of their manuscript. The citation for this article can be found on the "Publications" page of the website, under the tab titled "The Lab." Alternatively, the article can also be accessed here. This study aimed to inve...

June 29, 2018 The Matthews lab went out for a group lunch at Margarita's in order to celebrate Alice's birthday. Alice is undoubtedly the glue that holds the lab together and we would all be completely lost if it weren't for her keeping everyone in line. Here's to a fantastic birthday and a great long weekend, where Canada is celebrating it's 151st birthday, as well! Not that Alice is 151, of course.

  Between May 10th and May 13th, Dr. Matthews and Dr. Hamada attended the 70th Annual Congress of the Japan Society of Obstetrics and Gynaecology in Sendai City, Japan. This conference brings together clinicians and researchers from Japan and across the globe to discuss prominent issues within the field and share their own work. On May 11th, Dr. Matthews gave a presentation titled Prenatal Programming, Epigenetics, and Transgenerational Outcomes. More information about the conference...

  On Friday May 4th, 2018, the Department of Physiology at the University of Toronto celebrated the 38th annual Frontiers in Physiology (or "FIP") research day. This day brings together the members of all four research platforms in the department in order to share the outstanding work of our trainees. This year, FIP welcomed Dr. Mona Nemer as the Keynote Speaker. Dr. Nemer is an esteemed cardiac researcher and Canada's Chief Science Advisor. In addition to the tremendous work pres...